JenAge Publications

Author(s)	Title	Journal	Year	Volume	Pages	5-Year Impact Factor (JCR Edition 2014)	Links	Comments
Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M.	Impairing L-threonine catabolism promotes healthspan through methylglyoxal-mediated proteohormesis.	Cell Metab.	2018	27(4)	914-925
Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C.	Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.	Nat Commun.	2018	9(1)	327
Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A.	MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.	BMC Biol.	2017	15(1)	9
Baumgart M, Priebe S, Groth M, Hartmann N, Menzel U, Pandolfini L, Koch P, Felder M, Ristow M, Englert C, Guthke R, Platzer M, Cellerino A.	Longitudinal transcriptional analysis of vertebrate aging identifies mitochondrial complex I as a small molecule-sensitive modifier of lifespan.	Cell Syst.	2016	2(2)	122-132
Gebauer J, Gentsch C, Mansfeld J, Schmeißer K, Waschina S, Brandes S, Klimmasch L, Zamboni N, Zarse K, Schuster S, Ristow M, Schäuble S, Kaleta C.	Genome-scale database and reconstruction of Caenorhabditis elegans metabolism.	Cell Syst.	2016		S2405-4712(16)30151-X
Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, Hemmerich P.	Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-Seq.	PLoS One.	2016	11(5)	e0154531	3.234
Marthandan S, Menzel U, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Kaether C, Diekmann S.	Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.	Biol Res.	2016	49(1)	34
Reichwald K, Petzold A, Koch P, Downie BR, Hartmann N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino A, Englert C, Platzer M.	Insights into sex chromosome evolution and aging from the genome of a short-lived fish.	Cell.	2015	163(6)	1527-38	32.242
Wendler S, Hartmann N, Hoppe B, Englert C.	Age-dependent decline in fin regenerative capacity in the short-lived fish Nothobranchius furzeri.	Aging Cell.	2015	14(5)	857-66	6.340
Brodoehl S, Klingner C, Stieglitz K, Witte OW.	The impact of eye closure on somatosensory perception in the elderly.	Behav Brain Res.	2015	293	89-95	3.028
Brodoehl S, Klingner CM, Witte OW.	Eye closure enhances dark night perceptions.	Sci Rep.	2015	5	10515
Imam S, Schäuble S, Brooks AN, Baliga NS, Price ND.	Data-driven integration of genome-scale regulatory and metabolic network models.	Front Microbiol.	2015	6	409	3.989
Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M.	Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.	Nat Commun.	2015	6	10043	11.470
Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, Platzer P, Hemmerich P and Diekmann S.	Similarities in gene expression profiles during in vitro aging of primary human embryonic lung and foreskin fibroblasts.	Biomed Res Int.	2015	Article ID 731937	17 pages	1.579
Marthandan S, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Diekmann S.	Hormetic effect of rotenone in primary human fibroblasts	Immun Ageing	2015	12	11
Prell T, Hartung V, Tietz F, Penzlin S, Ilse B, Schweser F, Deistung A, Bokemeyer M, Reichenbach JR, Witte OW, Grosskreutz J.	Susceptibility-weighted imaging provides insight into white matter damage in amyotrophic lateral sclerosis.	PLoS One	2015	10(6)	e0131114	3.234
Baumgart M, Groth M, Priebe S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A.	RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.	Aging Cell.	2014	13(6)	965-74	6.340
Boehme M, Guenther M, Stahr A, Liebmann M. Jaenisch N, Witte OW, Frahm C.	Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice.	Neurosci Lett.	2014	572	7-12	2.030
Engelman C, Hahn U.	An empirically grounded approach to extend the linguistic coverage and lexical diversity of verbal probaqbilities.	In: CogSci 2014 - Proceedings of the 36th Annual Cognitive Science Conference. Cognitive Science Meets Artificial Intelligence: Human and Artificial Agents in Interactive Context. Quebec City, Quebeq, Canada, July 23-26, 2014.	2014		451-456
Franke K, Ristow M, Gaser C; Alzheimer‘s Disease Neuroimaging Initiative.	Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects.	Front Aging Neurosci.	2014	6	94	4.000
Hahn U, Engelmann C.	Grounding epistemic modality in speaker‘s judgements.	PRICAI 2014 - Proceedings of the 13th Pacific Rim International Conference on Artificial Intelligence. Gold Coast, Australie, 1-5 Dec 2014.	2014		654-687
Huehne R, Thalheim T, Suehnel J.	AgeFactDB - The JenAge ageing factor database - Towards data integration in ageing research.	Nucleic Acids Res.	2014	42(1)	D892-6	9.112
Jaenisch N, Popp A, Guenther M, Schnabel J, Witte OW, Frahm C.	Pro-apoptotic function of GABA-related transcripts following stroke.	Neurobiol Dis.	2014	70	237-44	3.652
Marthandan S, Priebe S, Hemmerich P, Klement K, Diekmann S.	Long-term quiescent fibroblast cells transit into senescence.	PLoS One	2014	9(12)	e115597	3.234
Marthandan S, Freeburn R, Steinbrecht S, Pawelec G, Barnett Y.	SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence‘ effects of ebselen and N-acetyl cysteine in human T cell clone cultures.	Immun Ageing	2014	11(1)	17	3.538
Münch S, Weidtkamp-Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, Pandolfi PP, Weißhart K, Hemmerich P.	The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is non-essential for DNA damage-induced fibroblast senescence.	Mol Cell Biol.	2014	34(10)	1733-46	4.777
Ristow M, Schmeisser K.	Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).	Dose Response.	2014	12(2)	288-341	1.217
Schleicher J, Guthke R, Dahmen U, Dirsch O, Holzhuetter HG, Schuster S.	A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease.	Biochim Biophys Acta (BBA) - Molecular and Cell Biology of Lipids	2014	1841(1)	62-9	5.162
Schuster S, Stark H.	What can we learn from Einstein and Arrhenius about the optimal flow of our blood?	Biochim Biophys Acta - General Subj.	2014	1840(1)	271-6	4.381
Segref A, Kevei É, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T.	Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.	Cell Metab.	2014	19(4)	642-52	17.565
Sieber MW, Guenther M, Jaenisch N, Albrecht-Eckardt D, Kohl M, Witte OW, Frahm C.	Age-specific transcriptional response to stroke.	Neurobiol Aging	2014	35(7)	1744-54	5.013
Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube S, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M	D-Glucosamine supplementation extends lifespan of nematodes and aging mice.	Nat Commun.	2014	5	3563	11.470
Brandtstädt S, Schmeisser K, Zarse K, Ristow M.	Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.	Aging (Albany NY).	2013	5(4)	270-5	6.432
Fuellen G, Boerries M, Busch H, de Grey AD, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D, Simm A.	In silico approaches and the role of ontologies in aging research.	Rejuvenation Res.	2013	16(6)	540-6	3.311
Graf M, Hartmann N, Reichwald K, Englert C.	Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri.	Exp Gerontol.	2013	48(1)	17-28	3.485
Petzold A, Reichwald K, Groth M, Taudien S, Hartmann N, Priebe S, Shagin D, Englert C and Platzer M.	The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels.	BMC Genomics.	2013	14	185	3.986
Priebe S, Menzel U, Zarse K, Groth M, Platzer M, Ristow M, Guthke R.	Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network.	PLoS One.	2013	8(10)	e77776	3.234
Priebe S, Menzel U.	Assignment of orthologous genes by utilization of multiple databases: the orthology package in R.	In: International Conference on Bioinformatics Models, methods and Algorithms. Barcelona, Spain, 11-14 February, 2013.	2013		105-110
Schäuble S, Stavraum AK, Puntervoll P, Schuster S, Heiland I.	Effect of substrate competition in kinetic models of metabolic networks.	FEBS Lett.	2013	587(17)	2818-2824	3.169
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.	Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.	Nat Chem Biol.	2013	9(11)	693-700	12.996
Schmeisser S, Priebe S, Groth M, Monajembashi S, Hemmerich P, Guthke R, Platzer M, Ristow M.	Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension.	Mol Metab.	2013	2(2)	92-102
Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JM, Guthke R, Platzer M, Zarse K, Ristow M.	Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension.	Aging Cell.	2013	12(3)	508-17	6.340
Sieber MW, Jaenisch N, Brehm M, Guenther M, Linnartz-Gerlach B, Neumann H, Witte OW, Frahm C.	Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.	PLoS One.	2013	8(1)	e52982	3.234
Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M.	Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data.	J Biol Chem.	2013	288(48)	34555-66	4.573
Baumgart M, Groth M, Priebe S, Appelt J, Guthke R, Platzer M, Cellerino A.	Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri.	Mech Ageing Dev.	2012	133(5)	226-33	3.397
Beisswanger E, Hahn U.	Towards valid and reusable reference alignments - Ten basic quality checks for ontology alignments and their application to three different reference data sets.	J Biomed Semantics.	2012	3 Suppl 1	S4	2.262
Buyko E, Beisswanger E, Hahn U.	The extraction of pharmacogenetic and pharmacogenomic relations – A case study using PharmGKB	Pac Symp Biocomput.	2012		367-87
Fuellen G, Dengjel J, Hoeflich A, Hoeijmakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J.	Systems biology and bioinformatics in ageing research: A workshop report	Rejuvenation Res.	2012	15(6)	631-41	3.311
Gaser C, Schmidt S, Metzler M, Herrmann KH, Krumbein I, Reichenbach JR, Witte OW.	Deformation-based brain morphometry in rats.	Neuroimage.	2012	63(1)	47-53	6.357
Gebauer J, Schuster S, de Figueiredo L, Kaleta C.	Detecting and investigating substrate cycles in a genome-scale human metabolic network.	FEBS J.	2012	279(17)	3192-202	4.001
Gossmann TI, Ziegler M, Puntervoll P, de Figueiredo LF, Schuster S, Heiland I.	NAD(+) biosynthesis and salvage - a phylogenetic perspective.	FEBS J.	2012	279(18)	3355-63	4.001
Hahn U, Beisswanger E, Buyko E, Faessler E, Traumüller J, Schröder S, Hornbostel K.	Iterative refinement and quality checking of annotation guidelines: How to deal effectively with semantically sloppy named entity types, such as pathological phenomena.	In: LREC 2012 – Proceedings of the 8th International Conference on Language Resources and Evaluation. Istanbul, Turkey, May 21-27, 2012. Paris: European Language Resources Association (ELRA).	2012		3881-85
Hahn U, Cohen KB, Garten Y, Shah NH.	Mining the pharmacogenomics literature--a survey of the state of the art.	Brief Bioinform.	2012	13(4)	460-94	9.617
Hahn U, Beisswanger E, Buyko E, Faessler E.	Active Learning-based corpus annotation--the PathoJen experience.	AMIA Annu Symp Proc.	2012	2012	301-10
Hartmann N, Englert C.	A microinjection protocol for the generation of transgenic killifish (Species: Nothobranchius furzeri).	Dev Dyn.	2012	241(6)	1133-41	2.376
Kaleta C, de Figueiredo LF, Schuster S.	Against the stream: Relevance of gluconeogenesis from fatty acids for natives of the arctic regions.	Int J Circumpolar Health.	2012	71	18436	0.701
Kirschner J, Weber D, Neuschl C, Franke A, Böttger M, Zielke L, Powalsky E, Groth M, Shagin D, Petzold A, Hartmann N, Englert C, Brockmann GA, Platzer M, Cellerino A, Reichwald K.	Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age research.	Aging Cell.	2012	11(2)	252-61	6.340
Klement K, Melle C, Murzik U, Diekmann S, Norgauer J, Hemmerich P.	Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging.	Mech Ageing Dev.	2012	133(7)	508-22	3.397
Schäuble S, Klement K, Marthandan S, Münch S, Heiland I, Schuster S, Hemmerich P, Diekmann S.	Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts.	PLoS One	2012	7(8)	e42150	3.234
Schmidt S, Bruehl C, Frahm C, Redecker C, Witte OW.	Age dependence of excitatory-inhibitory balance following stroke.	Neurobiol Aging.	2012	33(7)	1356-63	5.013
Tozzini E, Baumgart M, Battistoni G, Cellerino A.	Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: Localization of neurogenic niches, molecular characterization and effects of aging.	Aging Cell.	2012	11(2)	241-51	6.593
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M.	Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.	Cell Metab.	2012	15(4)	451-465	17.565
Antonow-Schlorke I, Schwab M, Cox LA, Li C, Stuchlik K, Witte OW, Nathanielsz PW, McDonald TJ.	Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability.	Proc Natl Acad Sci U S A.	2011	108(7)	3011-6	9.674		San Antonio Express News on the paper ( )
Beisswanger E, Hahn U.	“Of Mice and Men” revisited – Basic quality checks for reference alignments applied to the human-mouse anatomy alignment.	In: Bio-Ontologies 2011– Proceedings of the 11th Bio-Ontologies Workshop @ ISMB 2011. Vienna, Austria, July 15-16, 2011.	2011
Beuster G, Zarse K, Kaleta C, Thierbach R, Kiehntopf M, Steinberg P, Schuster S, Ristow M.	Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.	J Biol Chem.	2011	286	22323-30	4.573
Buyko E, Hahn U.	Generating semantics for the life sciences via text analytics.	ICSC 2011 – Proceedings of the 5th IEEE International Conference on Semantic Computing. Stanford University, CA, USA, September 19-21, 2011.	2011		193-6
Buyko E, Linde J, Priebe S, Hahn U.	Towards automatic pathway generation from biological full-text publications.	In: Gama J,Bradley E, Hollmen J. (Eds.), Advances in Intelligent Data Analysis X. IDA 2011 – Proceedings of the 10th International Conference on Intelligent Data Analysis. Porto, Portugal, October 29-31, 2011. Springer, (Lecture Notes in Computer Science, 7014).	2011	7014	67-79
de Figueiredo LF, Gossmann TI, Ziegler M, Schuster S.	Pathway analysis of NAD+ metabolism.	Biochem J.	2011	439(2)	341-8	4.396
Hartmann N, Reichwald K, Wittig I, Dröse S, Schmeisser S, Lück C, Hahn C, Graf M, Gausmann U, Terzibasi E, Cellerino A, Ristow M, Brandt U, Platzer M, Englert C.	Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri.	Aging Cell.	2011	10(5)	824-31	6.340
Kaleta C, de Figueiredo LF, Werner S, Guthke R, Ristow M, Schuster S.	In silico evidence for gluconeogenesis from fatty acids in humans.	PLoS Comput Biol.	2011	7(7)	e1002116	4.620
Priebe S, Linde J, Albrecht D, Guthke R, Brakhage AA.	FungiFun: A web-based application for functional categorization of fungal genes and proteins.	Fungal Genet Biol.	2011	48(4)	353-8	2.587
Ristow M, Schmeisser S.	Extending life span by increasing oxidative stress.	Free Radic Biol Med.	2011	51(2)	327-36	5.746
Schmeisser S, Zarse K, Ristow M.	Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.	Horm Metab Res.	2011	43(10)	687-92	2.121
Sieber MW, Claus RA, Witte OW, Frahm C.	Attenuated inflammatory response in aged mice brains following stroke.	PLoS One.	2011	6(10)	e26288	3.234
Zarse K, Bossecker A, Müller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M.	The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.	Horm Metab Res.	2011	43(4)	241-3	2.121
Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M.	Low-dose lithium uptake promotes longevity in humans and metazoans.	Eur J Nutr.	2011	50(5)	387-9	3.467		Spiegel interview with M. Ristow ( )
Beisswanger E, Wermter J, Hahn U.	Aligning UniProt and MeSH - A case study on human protein terms.	In: MedInfo 2010 – Proceedings of the 13th World Congress on Medical Informatics. Cape Town, South Africa, September 12-15, 2010. IOS Press, pp.1030-4 (Studies in Health Technology and Informatics, 160)	2010		1030-4
Buyko, Hahn U.	Evaluating the impact of alternative dependency graph encodings on solving event extraction tasks.	In: EMNLP 2010 – Proceedings of the 2010 Conference on Empirical Methods in Natural Language Processing. M.I.T., Boston, MA, USA, October 9-11, 2010. Stroudsburg/PA: Association for Computational Liguistics.	2010		982-992
Fuellen G, Adjaye J, de Grey A, Lepperdinger G, de Magalhães JP, Sühnel J, Wipat A.	Bioinformatics in ageing research: A workshop report.	Rejuvenation Res.	2010	13(6)	763-7	3.311
Hahn U, Tomanek E, Beiswanger E, Faessler E.	A proposal for a configurable silver standard.	In: LAW IV @ ACL 2010 – Proceedings of the 4th Linguistic Annotation Workshop. Uppsala, Sweden, July 15-16, 2010. Stroudsburg/PA: Association for Computational Linguistics.	2010		235-242
Kuhlow D, Florian S, von Fugura G, Weimer S, Schulz N, Petzke KJ, Zarse K, Pfeiffer AFH, Rudolph KL, Ristow M.	Telomerase deficiency impairs glucose metabolism and insulin secretion.	Aging (Albany NY).	2010	2(10)	650-8	6.432
Schulz TJ, Westermann D, Isken F, Voigt A, Laube B, Thierbach R, Kuhlow D, Zarse K, Schomburg L, Pfeiffer AF, Tschöpe C, Ristow M.	Activation of mitochondrial energy metabolism protects against cardiac failure.	Aging (Albany NY).	2010	2(11)	843-53	6.432
Thierbach R, Drewes G, Fusser M, Voigt A, Kuhlow D, Blume U, Schulz TJ, Reiche C, Glatt H, Epe B, Steinberg P, Ristow M.	The Friedreich‘s ataxia protein frataxin modulates DNA excision repair in prokaryotes and mammals.	Biochem J.	2010	432(1)	165-72	4.396
Zarse K, Schmeisser S, Birringer M, Falk E, Schmoll D, Ristow M.	Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans.	Horm Metab Res.	2010	42(12)	837-9	2.121