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JenAge News - June 23, 2011

Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri.

Jena-based authors including researchers from the Jena Centre for Systems Biology of Ageing − JenAge report new findings on the age dependence of mitochondrial function in the short-lived fish Nothobranchius furzeri, a new vertebrate model organism for ageing studies in the journal Aging Cell. Despite the short lifespan, ageing in N. furzeri is associated with a decline in mtDNA copy number, the down-regulation of mtDNA-associated genes, and an impairment of mitochondrial function.

Hartmann N, Reichwald K, Wittig I, Dröse S, Schmeisser S, Lück C, Graf M, Gausmann U, Terzibasi E, Cellerino A, Ristow M, Brandt U, Platzer M, Englert C:
Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri.
Aging Cell. 2011; [Epub ahead of print]

Fritz Lipmann Institute Press Release: [In german]