Genome Analysis

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Matthias Platzer (Group Leader)

Functional genomics of variations determining the susceptibility to complex disorders. Sequence analysis of eukaryotic model organisms, prokaryotes and metagenomes. Development of bioinformatic databases and analysis tools. Alternative splicing. Matthias Platzer has coordinated the Genome Sequencing Consortium within the German Human Genome Project 2000-2004.

For more information look at the Genome Analysis Group page of the Fritz Lipmann Institute (FLI).

Selected Publications

• Sinha R, Lenser T, Jahn N, Gausmann U, Friedel S, Szafranski K, Huse K, Rosenstiel P, Hampe J, Schuster S, Hiller M, Backofen R, Platzer M:
  TassDB2 - a comprehensive database of subtle alternative splicing events.
  BMC Bioinformatics. 2010; 11:216.
• Siddiqui RA, Sauermann U, Altmuller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup FJ, Stahl-Hennig C, Nurnberg P, Krawczak M, Platzer M:
  X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women.
  Am J Hum Genet. 2009; 85:228-39.
• Groth M, Szafranski K, Taudien S, Huse K, Mueller O, Rosenstiel P, Nygren AO, Schreiber S, Birkenmeier G, Platzer M:
  High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.
  Hum Mutat. 2008; 29:1247-54.
• Hiller M, Platzer M:
  Widespread and subtle: alternative splicing at short-distance tandem sites.
  Trends Genet. 2008; 24:246-55.
• Nusbaum C, ..., Taudien S, ..., Blechschmidt K, ..., Glöckner G, ..., Lehmann R, ..., Menzel U, ..., Polley A, ..., Reichwald K, ..., Schilhabel M, Siddiqui R, ..., Wen G, ..., Rosenthal A, ..., Platzer M, Shimizu N, Lander ES:
  DNA sequence and analysis of human chromosome 8.
  Nature. 2006; 439:331-5.